Research & Extension
M. Phil. and Ph.D. programs are offered in Zoology, Botany, Microbilogy and Biotechnology by
research. Dissertation is an important component of the postgraduate programs. Students are also
encouraged to work in National Institutes in the vacation.
Research Interests of the Faculty
Prof. S. Mohan Karuppayil
One of the major thrust areas of Research of the school could be said as the Bioprospecting of
local Biodiversity for Useful compounds. One of the ongoing projects funded by the Maharashtra
State Cell on Science and Technology (Dr. K.S. Mohan and Dr. B. S. Surwase) is on the
exploration of a wild plant as an import substitute for the well-known crude drug, Licorice. Our
studies have shown that this plant could be a source of useful bioactivities which include, antiinflammatory,
anti fungal, antibacterial, cytotoxic, anti- germ tube formation in Candida
albicans, protection from mutagenicity to cite a few. Another CSIR (SRF) project deals with the
exploration and identification of plant molecules as inhibitors of filamentous growth by the
human fungal pathogen Candida albicans. Regulation of phenotypic switching and identification
of anti- fungal targets in infectious fungi is the major area of research directed by. A study is
undertaken on the anti-fungal drug sensitivity of clinical isolates of Candida albicans from
Nanded. This study has identified Dose dependent sensitivity to anti-fungal agents like
Fluconazole among clinical isolates of Candida albicans.
Dr. G. Gyananth
His major research areas of interest includes Environmental Biotechnology research. Studies
on ecologically bioactive compounds from shellfish waste and Bioremediation. Fermentative
production of some of the biopolymers is done and their antibacterial activities are studied.
Methods have been standardized for the antibiotic resistance of coliforms from wastewater
samples. Emergence of antibiotic resistance is reported among environmental isolates. The effects
of neem extracts on fry of fishes, biomonitoring of water bodies, Water quality Assessment,
Restoration of Ecology, and Bioremediationare some of the research areas pursued in his Major
research project funded by the UGC on Aldose Reductase inhibition was successfully completed.
Dr. C. N. Khobragade
Enzyme production, characterization and immobilization for the industrial and clinical
purpose. Development of antigout drug from phytochemicals. Development of therapy using
phytochemicals against urolithoasis. Digitization of indigenous medicinal plant recourses.
Drug development against urinary tract infection causing organisms using wetlaband insilico
approach. Production of biofuels using algae. The Major research projects ongoing in the
laboratory are - 1. Drug development against grouti arthritis. 2. Search for role of
phytochemicals as antiurolithic agents. 3. Development of drug against urinary tract infection
causing microorganisms. 4. Digitization of indigenous plant recourses.
Dr. A. P. Pathak
has carried out studies on the Development of vaccines against Herpes Viruses using Bioinformatics
approaches. Herpes virus infections, colloquially known as Nagin, are becoming a major Health
issue. One of the approaches to prevent the infection from herpes viruses is to develop effective
vaccines. Subsequently traditional vaccines like, live attenuated and killed viral preparations were
developed and discontinued due to several reasons. One of the major problems is the reversion of
pathogenecity of attenuated viruses. This has encouraged the attempts to develop subunit
vaccines through the use of Bioinformatics based technologies. Glycoprotein sequences, the
integral part of virus coat proteins have been downloaded from the protein data banks. These
Glycoprotein H sequences were aligned using Clustlw package to locate the conserved regions.
The Glycoprotein H sequence aligned revealed divergence of the Herpes Viruses. The conserved
amino acid sequences of the Glycoprotein H has been scanned using various computer programs
to find out structural details like Helix, sheet or turn motifs. The amphipathic and antigenic index
has also been determined. The sequence motifs that exhibited high antigenic index, high
hydrophobic index and low hydrophilic index have been selected as epitopes that may stimulate
the immune system of the host. The Immunogenic peptides could be developed in to a subunit
vaccine. She has carried out studies on the development of peptide assay for identification of
HSV-1 virus using bioinformatics approach. She is working on the isolation and identification of
extremophiles from different locations like hot springs (Unkeshwar, Nanded), Lonar Mateorite
impact cretor lake in Buldhana district, Maharashtra, working on the isolation and identification
of industrially important enzymes producers. She is recognized guide in Biotechnology.
Dr. T. A. Kadam
conducts and guides research in Microbiology and Microbial Technology. He recently completed
a UGC minor research project on the Development of Biofertilisers. Excessive use of inorganic
fertilizers and plant protection agents (Pesticides) for maximizing crop yield and changes in
traditional cultivation practices has resulted in deterioration of chemical, physical and biological
health of cultivated land. Free-living nitrogen fixing microorganisms play very important role in
soil fertility. Many saprophytic microorganisms are known to degrade pesticides. However very
few reports are available on the role of nitrogen fixing organisms in the pesticide degradation.
Organisms with both capabilities may serve the purpose of application of biofertilizers and also
may solve the problem pesticide pollution of soil. The following studies are carried in the
Isolation of Azotobacter and Azospirillum from the soils of cultivated fields of Marathwada,
Study of biochemical characteristics, efficacy of the isolates on important crop plants,
Development of pesticide resistant strains through chemical and physical mutagenesis, Tolerance
of Azotobacter isolates to pesticides, analysis of pesticide degradation products, studies on
plasmids in pesticide degradation, Interactions between pesticide degrading isolates with other
microbes in soil and in the rhizosphere of a crop. Synergistic effect of other agrochemicals on the
pesticide degradation and Use of efficient pesticide degrading strains as biofertilizers.
Dr. Rajesh . N. Gacche
is working in the area of natural products and drug discovery. He has published several research
articalsin the area of anticancer research (Efficacy of natural products as antiangiogenicagents),
antioxidant potential of natural products etc. Dr. Gacche has delivered invited talks in the world
Ayurvedic congress held at Klagen forte, Austria. He was also invited to deliver in EPS Global
Health Summit held at Jiayagin, CHINA. University has recognized the work of Dr. Gacche and
awarded him the Best Teacherof the Year 2009. He has research projects from several funding
agencies like UGC, CSIR, DST etc.
Dr. B. S. Surwase
Guides Plant Biotechnology research. He is currently working on Taverniera cuneifolia an
alternative for Jeshtimadh (Glycyrrhiza glabra),Kali Jiri ( Vernonia anthelmintica) and Bibba
(Semecarpus anacardium) a popular drug used in Ayurvedic and other Traditional systems of
Medicine. This work is a part of the Projectsfunded by the UGC, New Delhi and Rajiv Gandhi
Science and technology Commission, Government of Maharashtra, Micropropogation techniques,
fast growing normal root cultur, Heavy root culture techniquesfor these plants is standardized in
the laborator. A Chemo and bio-activity profile for in-vitro produced secondary metabolites of
value in medicine and pharmaceutical industries is developed. In addition to this, a study is being
undertaken as a part of the project funded by RC: NAEB, MOEF, Mumbai to find out the status
of forest elements that have potential for the development of viable, small and medium scale
forest based enterprise in Dhule and Bhandara District of Maharashtra.
Dr. Chavan S. P.
His major thrust area of research is Cestode parasite Bio-geographical Diversity and host
specificity, Distribution and Molecular Taxonomy. Specially his interest is in the Cestode and
Nematode parasites from Freshwater fishes. Application of (SEM) Scanning Electron
Microscopic and (TEM) Transmission Electron Microscopic methods for the ultrastructural
Morphology and Anatomy for systematics in cestode parasites. Isolation of LSU rRNA for the
sequencing and COX I isolation for the phylogenetic studies. He is also working on the review
and recollection of reported species of Proteocephalid and Caryophyllid cestode parasites and
parasites from Elasmobranchs from west coast of India, from fresh water fishes in Marathwada
and western Ghats of Maharashtra. He is also working on the Freshwater leech ecology and
distribution, Leech therapy, Isolation and characterization of symbiotic bacterial species from the
leech species Asiaticobdella birmanica, Bioprospecting of leech from Marathwada region of
Maharashtra State. Heavy metal ion deposition in the cestode parasites as marker for heavy metal
ion bioaccumulation studies, Reservoir fisheries management and Aquaculture are his other
interests. Barcoding of cestode Parasites for their systematics. He has presented a research paper
in the 13th World Lake Conference, Wuhan, Hubei Province, China in October 2009 on the ‘
Fisheries Potential of reservoirs in Marathwada and reasons behind the low fish production’.
Visited the Institute of Parasitology, Czech Republic for one month Post Doctoral research in
fresh water fish Cestode parasite systematics, Poster presentation in the Workshop at University
of Kansas, USA for the Taxonomy of Cestode Parasites from vertebrates in July 2011 (7th
International Workshop on cestode systematics and phylogeny). He is working on the World
review Project on the Gangesia sp. a common tapeworm from freshwater fishes with the team of
scientists in Czech Republic and Slovak Republic for the recollection and review for the host and
Dr. R. M. Mulani
is working in the field of assessment of arbuscular mycorrhizal fungi from the campus of Swami
Ramanand Teerth Marathwada University, Nanded as well as the other localirties in Nanded area.
The study also includes assessment of colonization of AM Fungi in the roots of higher plants. The
flora of SRTM University campus is undertaken during this academic year and he has observed
number of medicinal plants occur in the S. R. T. M. University campus mainly include
Tylophora asthematica, Carraluma, Hemidesmus indicus etc. Some of the rare plants are
Ceropegia bulbosa, Iphiginia indica, Iphiginia pallida, Carraluma sp.. He is carrying out
research work on physicochemical properties of starch In perenating organs of tuberous plants
occur in wild Nanded area which can be used as an alternative sourse of starch for the trible
people. Some wild plants are eaten as leafy vegetables by the natives and analyzed for its
nutritive content. Variation in the taxonomical species are undertaken by using morphological,
phytochemical and molecular characters for the separation of sub-species. He is working on the
micropropogation of Vernonia antihelmintica and semicarpus anecardium L. which are important
medicinal plants occur in this area.
Dr. Zore Gajanan
Molecular Pharmacology, Plant Biotechnology. Regulation of dimorphism and virulence in Candida
albicans. Transplastomics, Natural products. Inducers specific proteomic analysis of hyphae and
role of differentially expressed proteins in virulence and dimorphism in Candida albicans. I
have taken up investigations on regulation of dimorphism to understand what lies beneath the
hyphae of C. albicans? This study is aimed at understanding ultra structure and identifying
differentially expressed protein (cytoplasmic and membrane) of C. albicans hyphae induced
under different stimulus conditions. Detailed characterization of differentially expressed proteins
using 2–D gel is currently in progress in my laboratory. Ultra structural study has revealed
difference in the hyphae (preliminary data of this study). I am also working on bioactive natural
products especially with immunomodulatory potential Plant Biotechnology -- Chloroplast
engineering proved to be an excellent alternative system for nuclear transformation in
recent past with several advantages. At present it is a prime necessity to optimize and
implement plastid engineering in plants with potent applications in agriculture and
industry to minimize bio safety concerns associated with nuclear transformation. We
are optimizing a process of transformation and transgene expression in chloroplast to generate
transplastomic of one of the economically important crop plant of Maharashtra.
Dr. Bhosale H. J.
Application of Azatobacter species in soil fertility. Isolation of useful microflora from
different cropfields. Bacterial enzymology and technology.
Dr. Nile S. H.
Main research Area: Biotechnology, Biochemistry, Bioinformatics, Medicinal Plants,
Biofules, Enzymes and pharmaceutical biotechnology. Research basically focuses on Protein
purification, Food chemistry, Natural Products, Enzymes, Enzyme Inhibition, Antioxidant,
Anti-inflammatory, Anticancer, Antibacterial, Antifungal study, Biofules, Medicinal plants,
microbial biochemistry and Medicinal Chemistry. In vitro, in vivo, in silico assay for
antioxidant, anti-inflammatory, anticancer, cytotoxicity and enzyme inhibition study. I am
along with our research group actively involved in isolation, purification and characterization
of Plant flavonoids. Sugars, secondary metabolites and their biological evaluation with
reference to in vitro, in vivo and in silico antioxidant, anti-inflammatory, anticancer and
cytotoxicity study. working in the area of Biotechnology, Bioinformatics and Clinical Data
Management and nanobiotechnology studies using softwares like Biomed Cache, PASS,
PALLAS, Discovery Studio etc; His interest is also to develop new methods and processes in
Biotechnology, Biochemistry, Enzymes, Proteins, Medicinal Plants, Biofules, Drug
Discovery, biochemical and Bioinformatics Research.